In a previous study of the effects of methandienone MENABOL on men undergoing athletic training, strength and performance increased, but not significantly more when the subjects were taking the drug than when they were taking placebo. The subjects did, however, gain more weight on the drug, with increases in total body potassium and muscle dimensions. It remained an open question whether the muscles had gained normal tissue or intracellular fluid. 2. In an attempt to distinguish between these possibilities the trial has been repeated, using as subjects seven male weight-lifters in regular training, and including measurements of total body nitrogen. As before, a dose of 100 mg of methandienone/day was given alternately with the placebo in a double-blind crossover experiment. The treatment periods lasted 6 weeks and were separated by an interval of 6 weeks. Body weight, potassium and nitrogen, muscle size, and leg performance and strength increased significantly during training on the drug, but not during the placebo period. 3. The finding of increased body nitrogen suggested that the weight gain was not only intracellular fluid. The increases in body potassium (436 +/- SEM 41 mmol) and nitrogen (255 +/- 69 g) were too large in proportion to the weight gain (2.3 +/- 0.4 kg) for this to be attributed to gain of normal muscle or other lean tissue, and imply gain of nitrogen-rich, phosphate-poor substance. Although this action of methandienone might be described as anabolic, the weight gain produced is not normal muscle._x000D__x000D_ _x000D__x000D_ Although it has been manufactured for decades, and many new steroids have been invented since Methandienone was first introduced, demand for Methandienone is still very strong. For most steroid users Methandienone becomes their first steroid cycle since it is a very popular compound with side-effects that are easily predictable. Since Methandienone is an oral steroid it is preferred by many people who are not ready to self-administer steroid injections. Even the top level Bodybuilders today continue to use Metandienone during their bulking cycles and off-season maintenance._x000D__x000D_ _x000D__x000D_ Menabol – Stanozolol, commonly sold under the name Winstrol (oral) and Winstrol Depot (intra-muscular)._x000D__x000D_ _x000D__x000D_ Unlike most injectable anabolic steroids, Menabol is not esterified and is sold as an aqueous suspension, or in oral tablet form. The drug has a large oral bioavailability, due to a C17 α-alkylation which allows the hormone to survive first pass liver metabolism when ingested. It is because of this that Menabol is also sold in tablet form._x000D__x000D_ _x000D__x000D_ Menabol is usually considered a safer choice for female bodybuilders in that it rewards a great amount of anabolism for a small androgenic effect, however virilization and masculinization are still very common, even at low doses._x000D__x000D_ _x000D__x000D_ Menabol has been used on both animal and human patients for a number of conditions. In humans, it has been demonstrated to be successful in treating anaemia and hereditary angioedema. Veterinarians may prescribe the drug to improve muscle growth, red blood cell production, increase bone density and stimulate the appetite of debilitated or weakened animals._x000D__x000D_ _x000D__x000D_ Menabol is one of the anabolic steroids commonly used as an ergogenic aid and is banned from use in sports competition under the auspices of the International Association of Athletics Federations (IAAF) and many other sporting bodies._x000D__x000D_ _x000D__x000D_ Menabol has also been used in US horse racing._x000D__x000D_ _x000D__x000D_ Menabol is used in the treatment of hereditary angioedema, which causes episodes of swelling of the face, extremities, genitals, bowel wall, and throat. Menabol may decrease the frequency and severity of these attacks._x000D__x000D_ New steroid users will sometimes use Methandienone alone as a first try into steroids, but that is not the best way to do it. Experienced bodybuilders use Methandienone in conjunction with other injectable steroids, preferrably testosterone cypionate or enanthate, during bulking cycles. Methandienone is used to boost muscle gains quickly during the first four weeks of an injectable and oral steroid stack. When used in the common dose range of 30mg to 50mg per day, any user can see an increase of weight by as much as 15lbs. Once Methandienone use is discontinued around week four, the injectable steroids begin to take effect and continue to solidify gains._x000D__x000D_ _x000D__x000D_ Methandienone_x000D__x000D_ is an oral steroid, which is commonly known by the name of Anabol or Danabol. It is structurally unstable with the ability to aromatize and hence become functionally useless. It is famous for its very powerful anabolic and androgenic effects in the body. It is preferred over many other commercially available steroids due to the ease of administration. It is taken orally while other steroids have to be injected intramuscularly and so daily visits to a doctor are required in the latter case._x000D__x000D_ _x000D__x000D_ Anabolic effects of methandienone_x000D__x000D_ are on protein metabolism where it prevents loss of proteins from the body and aids their accumulation. This action ensures adequate protein deposition in the muscles, increases lean body mass of the person, and enhances muscle power. It also allows sufficient amount of glycogen to be stored in the body._x000D__x000D_ Androgenic effects are beneficial for men where they too add to the muscle strength and reserve. Such effects however not favored by women because of issues like facial hair, enlargement of clitoris, deepening of voice, etc._x000D__x000D_ In addition to the beneficial effects, methandienone has several adverse effects that have decreased its popularity sufficiently in the past decade.